High-Order Multi-Task Feature Learning to Identify Longitudinal Phenotypic Markers for Alzheimer Disease Progression Prediction
Hua Wang, Feiping Nie, Heng Huang, Jingwen Yan, Sungeun Kim, Shannon Risacher, Andrew Saykin, Li Shen.
NIPS - 2012
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive impairment of memory and other cognitive functions. Regression analysis has been studied to relate neuroimaging measures to cognitive status. However, whether these measures have further predictive power to infer a trajectory of cognitive performance over time is still an under-explored but important topic in AD research. We propose a novel high-order multi-task learning model to address this issue. The proposed model explores the temporal correlations existing in imaging and cognitive data by structured sparsity-inducing norms. The sparsity of the model enables the selection of a small number of imaging measures while maintaining high prediction accuracy. The empirical studies, using the longitudinal imaging and cognitive data of the ADNI cohort, have yielded promising results.
Links
- View publications from Hua Wang
- View publications presented in NIPS
- View publications researching Longitudinal / Temporal Learning Models
- View publications researching Sparsity / Sparse Coding
- View publications applied to Medical Image Computing
Cite this paper
MLA
Wang, Hua, et al. "High-order multi-task feature learning to identify longitudinal phenotypic markers for alzheimer's disease progression prediction." Advances in neural information processing systems. 2012.
BibTeX
@inproceedings{wang2012high,
title={High-order multi-task feature learning to identify longitudinal phenotypic markers for alzheimer's disease progression prediction},
author={Wang, Hua and Nie, Feiping and Huang, Heng and Yan, Jingwen and Kim, Sungeun and Risacher, Shannon and Saykin, Andrew and Shen, Li},
booktitle={Advances in neural information processing systems},
pages={1277--1285},
year={2012}
}